PROBIOTICS, PREBIOTICS AND SYNBIOTICS
PROBIOTICS, information pills PREBIOTICS AND SYNBIOTICS
Hippocrates´ sayings from 4th century BC “death sits in the bowels” and “bad digestion is the root of all evil” are well known. Probiotics have revealed evidence of efficacy in more than 1000 RCTs from January 2000 till December 2012, viagra sale in relation to human health improvements in many ways.
Probiotics are living microorganisms, which are beneficial for the host. FAO/WHO define probiotics as “Live microorganisms which when administered in adequate amounts confer a health benefit on the host”. These microorganisms are instrumental for the intestinal microbial population by augmentation. Lactobacillus and Bifidobacterium are most widely used commercially and have been studied the most., 
Prebiotics are a food ingredient that is beneficial for the host’s digestive system and health by stimulating selectively the growth of some bacteria’s in the colon. Prebiotics are non-digestible and can stimulate the activity of the bacteria in the colon e.g. fructo-oligosaccharides (FOS), galacto-oligosaccharides (GOS), lactulose and inulin (sugar substitutes). Known prebotics are i.e. peptides, proteins, lipids and non-digestable oligosaccharides (NDOs).
Clear criteria are needed to classifying food ingredients as a prebiotic. According to Roberfroid these criteria are: “ 1) resistance to gastric acidity, to hydrolysis by mammalian enzymes, and to gastrointestinal absorption; 2) fermentation by intestinal microflora; and 3) selective stimulation of the growth and/or activity of those intestinal bacteria that contribute to health and well-being.”
Prebiotics, in some cases, might be beneficial for the probiotic (bifidobacteria especially) and that is “a synbiotic concept”. According to Andersson et al synbiotics are defined as “mixtures of probiotics and prebiotics that beneficially affect the host by improving the survival and implantation of live microbial dietary supplements in the gastrointestinal tract of the host”. Examples are FOS and Bifidobacterium and Lactitol and Lactobacillus together. Fermented milk products are good example.
THE COMPOSITION of the Human Gut Microbiota
Anaerobic bacteria (belonging to few of known bacterial phyla) are dominating in the adult’s human gut. Major phyla in a “normal” human gut are; Firmicutes (Gram-positive; low G+C; classes Bacilli /Clostridia) and Bacteriodetes (Gram-negative; genera Bacteroides / Prevotella / Alistipes). Proteobacteria (Gram-negative; genera Escherichia /Salmonella / Vibrio / Helicobacter), Verrumicrobia, Anctinobacteria (Gram-positve; high G+C; genus Bifidobacterium), Fusobacteria and Cyanobacteria are other species of the phyla Proteobacteria, which are also present in the gut.,, Bacteroidetes and Firmicutes dominate the distal gut microbiota. They constitute over ninety percent of the known phylogentetic categories. From the proximal to the distal gut, the microbial density increases along with increasing bacterial diversity and 300-500 different bacterial species are present only in the large intestines. There is marked diversity of the gut microbiome amongst healthy individuals, especially with infants, but with time the gut microbiome does converge to more similar phyla.,
THE ROLE of the Microbiota in the Gut
The microbes in our body, especially in the gut, play very important part in relation to nutrition and on human physiology. Microbes are very important for human life and all changes may influence the health of the host. Bowel diseases and obesity has been associated with changes of the gut microbiome.,,,, Beneficial homeostasis between the host and the microbiota must be ensured by restricted microbial growth in the intestines, where the mucosal immune system operates and tight regulation of the gut microbiota prevents chronic inflammation in the host. Several aspects of the immune tissues in the host are developed and directed by the intestinal micro-biota, as well as immune cell populations and immune mediators. According to Baugher et al6 probiotics are important for in the gastrointestinal tract. Probiotics help to suppress allergic asthma, decrease flue-like symptoms in children, lower serum cholesterol levels and protects against infection.,,,
IMPACTING Factors on the Microbiota Composition
Dysbiosis or dysbacteriosis is a microbial imbalance in the gut and first coined by Metchnikoff. When the microbiota produces harmful effects through quantitative as well as qualitative changes in the gut flora alongside changes in their metabolic activities and in their local distribution, it can be referred as a state of dysbiosis. The gut microbial ecosystem is modulated by the diet. Hydrogen sulfate inhibits oxidation of butyric acid leading to interrupted mucous and lipid synthesis for the coloncyte membranes and incomplete absorption of ions., Dietary changes can harm the beneficial flora in the gut as well as stress,,,,, (psychological and physical), radiation, chronic inflammation and metabolic dysfunction, hygiene, hyper-immunity (IL-6, IL-12, TNF) and altered GIT. The most common cause and the most significant one is the use of antibiotics. The influence depends on the spectrum of activity, length of administration, dosage and pharmacokinetics. When an antimicrobial agent is active against both gram-negative and gram-positive organisms, there will be greater impact on the gut flora., Altered intestinal flora can lead to several diseases e.g. asthma, obesity, cardiovascular diseases, arthritis and inflammatory bowel diseases.
PROBIOTIC Products and Major Marketing Issues in the EU
In December 2006 the Council and Parliament approved the Regulation on nutrition and health claims, which lays the rules across the EU. Regarding probiotics, specific health claims on foods are allowed, if sufficient evidence is available.,
PROBIOTIC Products and Major Consumption Issues in the EU
In Europe, the probiotic dairy products e.g. yogurts and milks account for 65% of the functional foods market. Products need to be made to fit the consumer’s health-beliefs and lifestyle and the target for marketing must be appropriate. Consumer researches have reviled that, predominately females, well-educated and high earners aged 35-55 years as well as being focused on their health, are typical functional-food-consumers. Future opportunities could lie in natural alternatives like probiotics to inhibit pathogens, as increasing resistance to antibiotics is becoming a major public health problem.
Probiotics, prebiotics and synbiotics are all important for humans to maintain healthy intestinal flora. The intestinal flora plays important role in human health, being sensitive to various influences. Dysbiosis is a microbial imbalance resulting from e.g. stress, diet, antibiotics, and infections. For the last decade researches have revealed good evidences on the importance of maintain healthy intestinal flora in sake of good health for the individual like preventing inflammation. Altered intestinal flora has been associated with diseases such as heart diseases, asthma, obesity and many more. There are limiting factors in relation to marketing probiotic products, which emphasizes the importance on continuing research for revealing therapeutic functionality on probiotic products.
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